What are the functions of matrine and oxymatrine in Sophora flavescens extract, respectively?
Date
- April 17, 2025
Table of Contents
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What are the sources of matrine and oxymatrine?
Matrine is extracted from the dried roots, plants, and fruits of the leguminous plant Sophora flavescens Ait through organic solvents such as ethanol. It is an alkaloid, generally the total alkaloid of Sophora flavescens. Its main components include various alkaloids such as matrine, sophora flavescens ait, oxysophora flavescens ait, and sophoridine, among which matrine and oxymatrine have the highest contents.
What are the functions of matrine?
- Diuretic effect.
Sophora flavescens, as a medicinal plant, mainly has the functions of clearing heat, promoting diuresis, killing parasites, and removing dampness. It also has multiple effects, such as antiviral, anti-tumor, and anti-allergic.
- Anti-pathogen effect.
It has an inhibitory effect on Mycobacterium tuberculosis. It has inhibitory effects of varying degrees on some common skin fungi in vitro.
Matrine is a natural plant-based pesticide with low toxicity to humans and animals. It is a broad-spectrum insecticide and has contact killing and stomach toxicity effects.
What are the characteristics of matrine?
- Green and environmentally friendly: Matrine is derived from nature and is compatible with the environment. It can be degraded or metabolized into simple natural compounds in the environment. Its active ingredients only contain carbon, hydrogen, and oxygen. The final products of its decomposition in the environment are carbon dioxide and water. It is the preferred agent for producing green and organic agricultural products.
- Broad spectrum of insecticidal and bactericidal effects: Matrine is derived from plants and is a general term for several alkaloids. It can not only kill insects but also treat diseases. Pests and diseases are less likely to develop resistance and have a high control effect on over 30 types of pests and diseases.
- Long-lasting effect: Matrine has a long-lasting effect of about 10 to 15 days, which is more than twice that of common chemical agents.
What are the functions of oxymatrine?
Oxymatrine has direct anti-inflammatory effects, immunomodulatory effects, inhibition of tumor proliferation, induction of differentiation and apoptosis, antiviral and bactericidal effects, anti-hypoxia, vasodilation, lipid-lowering, anti-arrhythmic, sedative, antipyretic, and improvement of various hemorheological indicators.
Antibacterial and anti-inflammatory.
Oxymatrine has broad-spectrum antibacterial properties. It can not only inhibit the biosynthesis of the bacteria but also affect the biological oxidation process of the bacteria. The anti-inflammatory mechanism of oxymatrine is caused by its stabilizing effect on erythrocyte membranes, and it has a strong immunomodulatory effect. It can exert its anti-inflammatory effect by influencing changes in immune cells, cytokines, and other inflammatory regulatory factors. It has a good therapeutic effect on eczema and dermatitis, and can relieve skin itching caused by inflammation. It is one of the three major plant-based soothing agents in the skincare industry (the other two being licorice extract and Scutellaria baicalensis extract), and is widely used in acne and anti-inflammatory cosmetics.
- Anti-allergy.
Oxymatrine can inhibit the release of histamine by mast cells caused by IgE and autoantigens, exerting an anti-allergic effect. It can suppress physical pain, chemical irritation pain, and neuropathic pain, and relieve skin pain caused by inflammation and allergy.
- Whitening.
Oxymatrine has the effect of inhibiting tyrosinase, suppressing the production of melanin, and has a whitening effect. By inhibiting tyrosinase, oxymatrine can reduce pigmentation caused by skin aging and ultraviolet radiation.
- Anti-wrinkle.
Oxymatrine has lower cytotoxicity than the anti-wrinkle agent retinol, and at the molecular level, it shows an inhibitory effect on collagenase activity and a promoting effect on collagen biosynthesis, and has the effect of improving skin wrinkles.
- Promote hair growth.
Oxymatrine has been proven to be an effective antibacterial agent, promoting new growth and circulation. Combined with extracts of other Chinese herbal medicines, it has anti-inflammatory, blood circulation-promoting promoting and cell regeneration effects, providing rich nutrition for hair and scalp.
What are the applications of oxymatrine?
The main application preparations for oxymatrine are oxymatrine injections, oxymatrine capsules, and tablets, which are mainly used for the treatment of hepatitis B and tumors.
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